How to Prescribe and Access IBSRELA

Get details on prescribing IBSRELA for your adult patients with IBS-C, copay program information, and accessing IBSRELA through the IBSRELA Pharmacy Network

The IBSRELA Pharmacy Network Is Here to Help Your Adult Patients Get Access to IBSRELA

IBSRELA Pharmacy Network

Prescribing IBSRELA Made Faster The IBSRELA Pharmacy Network consists of 12 contracted pharmacies and provides enhanced, consistent services for both you and your patients.

The goal of the network is to improve care coordination and the prior authorization process to help patients get IBSRELA faster

Benefits of the IBSRELA Pharmacy Network

Enhanced
services

Consistent
experience

Improved care
coordination

Prior
authorization
support

Get IBSRELA
faster

How to Prescribe Through the IBSRELA Pharmacy Network

Identify patients with Irritable Bowel Syndrome with Constipation (IBS-C) who may benefit from IBSRELA

Adult patients with a diagnosis of IBS-C (ICD-10: K58.1)¹*

e-Prescribe IBSRELA 50 mg BID to one of the pharmacies in the IBSRELA Pharmacy Network^†

Most insurances require a PA; CoverMyMeds^® is available to quickly and accurately submit the PA when a prescription is initiated

Patients can pay as little as $0^†—discount applied automatically at pharmacy

*The ICD-10 code is provided for informational purposes only. It is the treating physician’s responsibility to determine the proper diagnosis, treatment, and applicable ICD-10 code. Ardelyx, Inc. does not guarantee coverage or reimbursement for the product.

^†IBSRELA may be available at other pharmacies.

All trademarks, logos, and brand names are the property of their respective owners.

PA=prior authorization.

IBSRELA Pharmacy Network Partners

Submit prescriptions to any of our partners below:

Alto Pharmacy Phone: (800) 874-5881
Fax: (415) 484-7058
Hours of Operation:
Monday - Friday: 6am - 9pm (PT), Saturday - Sunday: 7am - 6pm (PT)
Servicing Patients: Nationwide
CenterWell Specialty Pharmacy Phone: (800) 486-2668
Fax: (877) 405-7940
Hours of Operation:
Monday - Friday: 8am - 11pm (ET), Saturday: 8am - 6:30pm (ET)
Servicing Patients: Nationwide
CVS Specialty Pharmacy Phone: (800) 237-2767
Fax: (800) 323-2445
Hours of Operation:
Monday - Friday: 8am - 8pm (ET)
Servicing Patients: Nationwide
Healthy Heights Pharmacy Phone: (212) 928-1999
Fax: (212) 928-1995
Hours of Operation:
Monday - Friday: 9am - 7pm (ET), Sunday: 10am - 3pm (ET)
Servicing Patients In: NY, NJ
LifeLine Specialty Pharmacy Phone: (833) 454-3354
Fax: (833) 785-4461
Hours of Operation:
Monday - Friday: 9am - 6:30pm (ET)
Servicing Patients: Nationwide
Perigon Pharmacy Three-Sixty Phone: (412) 684-2500
Fax: (724) 597-7275
Hours of Operation:
Monday - Friday: 9am - 6pm (ET)
Servicing Patients: Nationwide
Reliance Rx Specialty Pharmacy Phone: (716) 929-1000
Fax: (716) 532-7360
Hours of Operation:
Monday - Thursday: 8am - 8pm (ET), Friday: 7am - 8pm (ET)
Servicing Patients: Nationwide
Silver Care Pharmacy Phone: (718) 445-8585
Fax: (718) 445-8586
Hours of Operation:
Monday - Friday: 9am - 7pm (ET), Saturday: 9am - 6pm (ET)
Servicing Patients In: NY
Synergen Rx Pharmacy Phone: (888) 975-2191
Fax: (404) 900-9209
Hours of Operation:
Monday - Friday: 8:30am - 5pm (ET)
Servicing Patients: Nationwide
Walgreens Specialty Pharmacy
Send to any Walgreens location
Servicing Patients: Nationwide
Walmart Specialty Pharmacy Phone: (877) 453-4566
Fax: (866) 537-0877
Hours of Operation:
Monday - Friday: 9am - 9pm (ET), Saturday: 9am - 3pm (ET)
Servicing Patients: Nationwide
Transition Pharmacy Services (ArdelyxAssist)
Phone: (844) 427-7352 Option 1
Fax: (877) 765-7664
Hours of Operation:
Monday - Friday: 8am - 8pm (ET)
Servicing Patients: Nationwide

Ardelyx Offers Several Programs to Support Patient Affordability

Commercial patients can pay as little as zero dollars

With copay support automatically applied, patients may pay as little as $0^‡ per 30- or 90-day prescription

ArdelyxAssist is here to help. Call us at 1‑844‑427‑7352, Option 1, if you have any questions or need support with IBSRELA access or affordability
ArdelyxAssist offers additional programs for eligible patients who are uninsured or underinsured and are unable to afford IBSRELA

^‡Terms and conditions apply. For patients with commercial insurance.

Resources for You and Your Patients

IBSRELA Copay Program Download copay card

Sample Letter of Medical Necessity Download template

IBSRELA Dosing Information

IBSRELA Is Dosed as (1) 50-mg Tablet BID

Before treatment begins, help set dosing expectations by instructing patients as follows¹:

Take IBSRELA immediately prior to breakfast or the first meal of the day and immediately prior to dinner

If a dose is missed, skip the missed dose and take the next dose at the regular time

Do not take 2 doses at the same time

ARE YOUR PATIENTS READY TO FLIP THE SCRIPT? ASK THEM, “DO YOU WANT TO TRY SOMETHING DIFFERENT?”

Peer Perspectives

“The majority of my patients report they are happy with IBSRELA and want to continue on the medication.”

—Dr Jignesh Shah

Compensated advisor to Ardelyx

Frequently Asked Questions

What is the IBSRELA Pharmacy Network?

The IBSRELA Pharmacy Network consists of 12 contracted pharmacies. The benefits of the IBSRELA Pharmacy Network include enhanced, consistent services for both healthcare professionals and patients, prior authorization support, and improved coordination of care to help patients get IBSRELA faster.

How do I prescribe through the IBSRELA Pharmacy Network?

Identify adult patients diagnosed with Irritable Bowel Syndrome with Constipation (IBS-C) (ICD-10: K58.1)¹* who may benefit from IBSRELA, and e-prescribe 50 mg BID through a pharmacy in the IBSRELA Pharmacy Network^† (though availability may extend beyond the network).

^†IBSRELA may be available at other pharmacies.

What pharmacies are included in the IBSRELA Pharmacy Network?

There are 12 contracted pharmacies. For a complete list, please see our IBSRELA Pharmacy Network Partners and how to contact them.

Who can I contact for support around the IBSRELA Pharmacy Network?

Adult patients taking IBSRELA should contact their healthcare provider for questions about their prescription or if they were not contacted by a pharmacy.

For further questions on access and affordability, call ArdelyxAssist at 1-844-427-7352, Option 1.

What if I want to prescribe to a pharmacy outside of the IBSRELA Pharmacy Network?

IBSRELA may be available at other pharmacies in the IBSRELA Pharmacy Network. The best path to access IBSRELA is using the IBSRELA Pharmacy Network. Partner pharmacies in the IBSRELA Pharmacy Network provide enhanced services, including prior authorization support, and a consistent experience to help patients access IBSRELA faster.

If there are questions, or if not contacted by a pharmacy, adults taking IBSRELA should contact their healthcare provider for more information. For additional questions about access and affordability, give ArdelyxAssist a call at 1-844-427-7352, Option 1.

Who should I contact if I need help after prescribing IBSRELA?

If you need help after prescribing IBSRELA through the IBSRELA Pharmacy Network, contact your chosen pharmacy directly to get assistance. Please see our IBSRELA Pharmacy Network Partners for contact information.

What should I do if my preferred pharmacy no longer stocks IBSRELA?

If your preferred pharmacy no longer stocks IBSRELA, it does not mean it is not available. Please contact ArdelyxAssist at 1-844-427-7352, Option 1 and submit future prescriptions to the IBSRELA Pharmacy Network.

Reference:

1. IBSRELA [prescribing information]. Waltham, MA: Ardelyx, Inc.; 2025.

INDICATION

IBSRELA (tenapanor) is indicated for the treatment of Irritable Bowel Syndrome with Constipation (IBS-C) in adults.

IMPORTANT SAFETY INFORMATION

WARNING: RISK OF SERIOUS DEHYDRATION IN PEDIATRIC PATIENTS

IBSRELA is contraindicated in patients less than 6 years of age; in nonclinical studies in young juvenile rats administration of tenapanor caused deaths presumed to be due to dehydration. Avoid use of IBSRELA in patients 6 years to less than 12 years of age. The safety and effectiveness of IBSRELA have not been established in patients less than 18 years of age.

CONTRAINDICATIONS

IBSRELA is contraindicated in patients less than 6 years of age due to the risk of serious dehydration.
IBSRELA is contraindicated in patients with known or suspected mechanical gastrointestinal obstruction.

WARNINGS AND PRECAUTIONS

Risk of Serious Dehydration in Pediatric Patients

IBSRELA is contraindicated in patients below 6 years of age. The safety and effectiveness of IBSRELA in patients less than 18 years of age have not been established. In young juvenile rats (less than 1 week old; approximate human age equivalent of less than 2 years of age), decreased body weight and deaths occurred, presumed to be due to dehydration, following oral administration of tenapanor. There are no data available in older juvenile rats (human age equivalent 2 years to less than 12 years).
Avoid the use of IBSRELA in patients 6 years to less than 12 years of age. Although there are no data in older juvenile rats, given the deaths in younger rats and the lack of clinical safety and efficacy data in pediatric patients, avoid the use of IBSRELA in patients 6 years to less than 12 years of age.

Diarrhea

Diarrhea was the most common adverse reaction in two randomized, double-blind, placebo-controlled trials of IBS-C. Severe diarrhea was reported in 2.5% of IBSRELA-treated patients. If severe diarrhea occurs, suspend dosing and rehydrate patient.

MOST COMMON ADVERSE REACTIONS

The most common adverse reactions in IBSRELA-treated patients (incidence ≥2% and greater than placebo) were: diarrhea (16% vs 4% placebo), abdominal distension (3% vs <1%), flatulence (3% vs 1%) and dizziness (2% vs <1%).